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Pregnancy history linked to risk for Alzheimer’s disease

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WEDNESDAY, July 18, 2018 — A girl’s pregnancy history might predict her risk for creating Alzheimer’s disease, new analysis suggests.

“We found that women who had given birth to five or more children were 70 percent more likely to develop Alzheimer’s disease than women who gave birth to fewer children,” mentioned examine writer Dr. Ki Woong Kim, director of South Korea’s National Institute of Dementia.

Given prior analysis, Kim mentioned this discovering was not sudden.

But he and his colleagues have been “quite surprised” by a further discovering: that an incomplete pregnancy about halved the risk of Alzheimer’s in comparison to girls who by no means had a miscarriage or abortion.

Roughly two-thirds of Alzheimer’s sufferers within the United States are girls, in accordance to the Alzheimer’s Association.

Heather Snyder, the affiliation’s senior director of medical and scientific relations, mentioned, “We know Alzheimer’s and other dementias hit women harder than men, but we don’t know why.” Snyder had no function within the new analysis.

Kim’s staff checked out two research carried out in Korea and Greece. Together, they tracked pregnancy histories and Alzheimer’s onset amongst about 3,550 older girls.

The examine does not present a direct cause-and-effect relationship. But Kim believes fluctuation of the feminine hormone estrogen throughout pregnancy doubtless performs a job within the findings.

Estrogen, he famous, doubles by the eighth week of pregnancy, and ultimately reaches 40 instances peak pre-pregnancy ranges. Then it quickly falls off following childbirth.

And prior analysis means that greater estrogen ranges might supply some protection towards accumulation of beta amyloid plaque, which has been linked to the onset of Alzheimer’s, he famous.

Still, far more work is required so as “to find the mechanism that underlie(s) the association between pregnancy and the risk of Alzheimer’s disease,” mentioned Kim, a professor of psychiatry at Seoul National University College of Medicine.

On common, members within the two research have been 71 years outdated and had first given start 46 years earlier. None used hormone alternative remedy when the research launched, or had had a hysterectomy or surgical procedure to take away their ovaries.

Mental health exams revealed that 118 girls had Alzheimer’s, whereas practically 900 struggled with delicate cognitive impairment, the researchers reported.

After evaluating pregnancy histories towards psychological health histories, the reseachers concluded that Alzheimer’s risk was 68 p.c better amongst these with 5 or extra kids.

Of the 2,751 girls who had had fewer than 5 kids, simply 53 — lower than 2 p.c — developed Alzheimer’s, the findings confirmed. This in contrast with 59 of 716 — greater than 8 p.c — who had delivered 5 or extra infants.

Alzheimer’s risk was significantly decrease amongst those that had had a miscarriage or abortion, in accordance to the report. While 71 of practically 1,200 girls (6 p.c) with out an incomplete pregnancy developed the mind disease, that determine fell to 47 amongst practically 2,400 (2 p.c) who had had a pregnancy that by no means got here to time period.

The findings could also be essential in locations like Asia, the place multiple in 5 girls over 60 has had 5 or extra kids, the researchers famous. Likewise, in sub-Saharan Africa, 5 childbirths is common,

Kim urged that “it may be useful for medical doctors to identify reproductive histories to identify a high-risk group” for Alzheimer’s. These girls, he mentioned, would possibly profit from focused psychological health monitoring, hormonal remedy, an improved weight loss plan and common exercise.

But Snyder mentioned it is too early to make suggestions.

“The potential link between reproduction history and brain health is intriguing, but still very much in its early stages,” she famous.

“Reproductive history is just one area being studied, but a critical one,” she added. “The physical and hormonal changes that occur during pregnancy are considerable, and it’s important to understand what impact, if any, these changes may have on future brain health.”

Snyder urged that “much more study in this area is needed.”

The examine was printed on-line July 18 within the journal Neurology.

More data

There’s extra on dementia on the Alzheimer’s Association.

Copyright © 2018 HealthDay. All rights reserved.

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