Home Health News Safety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data

Safety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data

20 min read
0
0
2

  • 1.

    Hormone remedy for sexual dysfunction: the one “true aphrodisiac”.

    Postgrad Med. 1983; 74: 78-80

  • 2.
    • Somboonporn W
    • Davis S
    • Seif M
    • Bell R

    Testosterone for peri- and postmenopausal girls.

    Cochrane Database Syst Rev. 2005; 4CD004509

  • 3.
    • Achilli C
    • Pundir J
    • Ramanathan P
    • Sabatini L
    • Hamoda H
    • Panay N

    Efficacy and security of transdermal testosterone in postmenopausal girls with hypoactive sexual want dysfunction: a systematic review and meta-analysis.

    Fertil Steril. 2017; 107: 475-482

  • 4.
    • Moher D
    • Liberati A
    • Tetzlaff J
    • Altman DG

    Preferred reporting gadgets for systematic critiques and meta-analyses: the PRISMA assertion.

    Ann Intern Med. 2009; 151: 264-269

  • 5.
    • Islam RM
    • Bell RJ
    • Green S
    • Davis SR

    Effects of testosterone remedy for girls: a systematic review and meta-analysis protocol.

    Syst Rev. 2019; 8: 19

  • 6.
    • European Medicines Agency

    Scientific dialogue: INTRINSA testosterone transdermal patch.

  • 7.

    Procter & Gamble Pharmaceuticals. Advisory committee briefing doc: Intrinsa (testosterone transdermal system) NDA no 21-769. Dec 2, 2004. https://wayback.archive-it.org/7993/20170405114619/https://www.fda.gov/ohrms/dockets/ac/04/briefing/2004-4082B1_01_A-P&G-Intrinsa.pdf (accessed July 3, 2019).

  • 8.
    • Davis SR
    • Moreau M
    • Kroll R
    • et al.

    Testosterone for low libido in postmenopausal girls not taking estrogen.

    N Engl J Med. 2008; 359: 2005-2017

  • 9.
    • Higgins JP
    • Altman DG
    • Gøtzsche PC
    • et al.

    The Cochrane Collaboration’s software for assessing danger of bias in randomised trials.

    BMJ. 2011; 343d5928

  • 10.

    Meta-analysis in medical trials.

    Control Clin Trials. 1986; 7: 177-188

  • 11.
    • Riley RD
    • Higgins JP
    • Deeks JJ

    Interpretation of random results meta-analyses.

    BMJ. 2011; 342: d549

  • 12.
    • Sterne JA
    • Sutton AJ
    • Ioannidis JP
    • et al.

    Recommendations for analyzing and deciphering funnel plot asymmetry in meta-analyses of randomised controlled trials.

    BMJ. 2011; 343d4002

  • 13.
    • Rakap S
    • Rakap S
    • Evran D
    • Cig O

    Comparative analysis of the reliability and validity of three data extraction packages: UnGraph, GraphClick, and DigitizeIt.

    Comput Human Behav. 2016; 55: 159-166

  • 14.

    Cochrane handbook for systematic critiques of interventions, model 5.1.0.

  • 15.
    • Barrett-Connor E
    • Young R
    • Notelovitz M
    • et al.

    A two-year, double-blind comparability of estrogen-androgen and conjugated estrogens in surgically menopausal girls: results on bone mineral density, signs and lipid profiles.

    J Reprod Med. 1999; 44: 1012-1020

  • 16.
    • Basaria S
    • Nguyen T
    • Rosenson RS
    • Dobs AS

    Effect of methyl testosterone administration on plasma viscosity in postmenopausal girls.

    Clin Endocrinol. 2002; 57: 209-214

  • 17.
    • Braunstein GD
    • Sundwall DA
    • Katz M
    • et al.

    Safety and efficacy of a testosterone patch for the therapy of hypoactive sexual want dysfunction in surgically menopausal girls: a randomized, placebo-controlled trial.

    Arch Intern Med. 2005; 165: 1582-1589

  • 18.
    • Buster JE
    • Kingsberg SA
    • Aguirre O
    • et al.

    Testosterone patch for low sexual want in surgically menopausal girls: a randomized trial.

    Obstet Gynecol. 2005; 105: 944-952

  • 19.
    • Davis S
    • Papalia MA
    • Norman RJ
    • et al.

    Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in premenopausal girls: a randomized trial.

    Ann Intern Med. 2008; 148: 569-577

  • 20.
    • Davis SR
    • Hirschberg AL
    • Wagner LK
    • Lodhi I
    • von Schoultz B

    The impact of transdermal testosterone on mammographic density in postmenopausal girls not receiving systemic estrogen remedy.

    J Clin Endocrinol Metab. 2009; 94: 4907-4913

  • 21.
    • Davis SR
    • Jane F
    • Robinson PJ
    • et al.

    Transdermal testosterone improves verbal studying and reminiscence in postmenopausal girls not on oestrogen remedy.

    Clin Endocrinol. 2014; 81: 621-628

  • 22.
    • Davis SR
    • McCloud P
    • Strauss BJ
    • Burger H

    Testosterone enhances estradiol’s results on postmenopausal bone density and sexuality.

    Maturitas. 1995; 21: 227-236

  • 23.
    • Davis SR
    • van der Mooren MJ
    • van Lunsen RH
    • et al.

    Efficacy and security of a testosterone patch for the therapy of hypoactive sexual want dysfunction in surgically menopausal girls: a randomized, placebo-controlled trial.

    Menopause. 2006; 13: 387-396

  • 24.
    • Davis SR
    • Walker KZ
    • Strauss BJG

    Effects of estradiol with and with out testosterone on physique composition and relationships with lipids in postmenopausal girls.

    Menopause. 2000; 7: 395-401

  • 25.
    • de Paula FJF
    • Soares Jr, JM
    • Haidar MA
    • de Lima GR
    • Baracat EC

    The advantages of androgens mixed with hormone substitute remedy relating to to sufferers with postmenopausal sexual signs.

    Maturitas. 2007; 56: 69-77

  • 26.
    • Dias RS
    • Kerr-Correa F
    • Moreno RA
    • et al.

    Efficacy of hormone remedy with and with out methyltestosterone augmentation of venlafaxine within the therapy of postmenopausal depression: a double-blind controlled pilot examine.

    Menopause. 2006; 13: 202-211

  • 27.
    • Dobs AS
    • Nguyen T
    • Pace C
    • Roberts CP

    Differential results of oral estrogen versus oral estrogen-androgen substitute remedy on physique composition in postmenopausal girls.

    J Clin Endocrinol Metab. 2002; 87: 1509-1516

  • 28.
    • El-Hage G
    • Eden JA
    • Manga RZ

    A double-blind, randomized, placebo-controlled trial of the impact of testosterone cream on the sexual motivation of menopausal hysterectomized girls with hypoactive sexual want dysfunction.

    Climacteric. 2007; 10: 335-343

  • 29.
    • Floter A
    • Nathorst-Boos J
    • Carlstrom Okay
    • Ohlsson C
    • Ringertz H
    • Von Schoultz B

    Effects of mixed estrogen/testosterone remedy on bone and physique composition in oophorectomized girls.

    Gynecol Endocrinol. 2005; 20: 155-160

  • 30.
    • Floter A
    • Nathorst-Boos J
    • Carlstrom Okay
    • von Schoultz B

    Addition of testosterone to estrogen substitute remedy in oophorectomized girls: results on sexuality and well-being.

    Climacteric. 2002; 5: 357

  • 31.
    • Floter A
    • Nathorst-Boos J
    • Carlstrom Okay
    • von Schoultz B

    Serum lipids in oophorectomized girls throughout estrogen and testosterone substitute remedy.

    Maturitas. 2004; 47: 123-129

  • 32.
    • Fooladi E
    • Bell RJ
    • Jane F
    • Robinson PJ
    • Kulkarni J
    • Davis SR

    Testosterone improves antidepressant-emergent loss of libido in girls: findings from a randomized, double-blind, placebo-controlled trial.

    J Sex Med. 2014; 11: 831-839

  • 33.
    • Goldstat R
    • Briganti E
    • Tran J
    • Wolfe R
    • Davis SR

    Transdermal testosterone remedy improves well-being, temper, and sexual perform in premenopausal girls.

    Menopause. 2003; 10: 390-398

  • 34.
    • Gruber DM
    • Sator MO
    • Kirchengast S
    • Joura EA
    • Huber JC

    Effect of percutaneous androgen substitute remedy on physique composition and physique weight in postmenopausal girls.

    Maturitas. 1998; 29: 253-259

  • 35.
    • Hickok LR
    • Toomey C
    • Speroff L

    A comparability of esterified estrogens with and with out methyltestosterone: results on endometrial histology and serum lipoproteins in postmenopausal girls.

    Obstet Gynecol. 1993; 82: 919-924

  • 36.
    • Hofling M
    • Hirschberg AL
    • Skoog L
    • Tani E
    • Hagerstrom T
    • von Schoultz B

    Testosterone inhibits estrogen/progestogen-induced breast cell proliferation in postmenopausal girls.

    Menopause. 2007; 14: 183-190

  • 37.
    • Hofling M
    • Lundstrom E
    • Azavedo E
    • Svane G
    • Hirschberg AL
    • von Schoultz B

    Testosterone addition throughout menopausal hormone remedy: results on mammographic breast density.

    Climacteric. 2007; 10: 155-163

  • 38.
    • Huang G
    • Basaria S
    • Travison TG
    • et al.

    Testosterone dose-response relationships in hysterectomized girls with or with out oophorectomy: results on sexual perform, physique composition, muscle efficiency and bodily perform in a randomized trial.

    Menopause. 2014; 21: 612-623

  • 39.
    • Huang G
    • Pencina KM
    • Coady JA
    • Beleva YM
    • Bhasin S
    • Basaria S

    Functional voice testing detects early modifications in vocal pitch in girls throughout testosterone administration.

    J Clin Endocrinol Metab. 2015; 100: 2254-2260

  • 40.
    • Huang G
    • Tang E
    • Aakil A
    • et al.

    Testosterone dose-response relationships with cardiovascular danger markers in androgen-deficient girls: a randomized, placebo-controlled trial.

    J Clin Endocrinol Metab. 2014; 99: E1287-E1293

  • 41.
    • Huang G
    • Wharton W
    • Travison TG
    • et al.

    Effects of testosterone administration on cognitive perform in hysterectomized girls with low testosterone ranges: a dose-response randomized trial.

    J Endocrinol Invest. 2015; 38: 455-461

  • 42.
    • Kocoska-Maras L
    • Hirschberg AL
    • Bystrom B
    • Schoultz BV
    • Radestad AF

    Testosterone addition to estrogen remedy: results on inflammatory markers for heart problems.

    Gynecol Endocrinol. 2009; 25: 823-827

  • 43.
    • Leao LMCSM
    • Duarte MPC
    • Silva DMB
    • Bahia PBV
    • Coeli CM
    • Fleiuss de Farias ML

    Influence of methyltestosterone postmenopausal remedy on plasma lipids, inflammatory elements, glucose metabolism and visceral fats: a randomized examine.

    Eur J Endocrinol. 2006; 154: 131-139

  • 44.
    • Liu J
    • Allgood A
    • Derogatis LR
    • et al.

    Safety and efficacy of low-dose esterified estrogens and methyltestosterone, alone or mixed, for the therapy of sizzling flashes in menopausal girls: a randomized, double-blind, placebo-controlled examine.

    Fertil Steril. 2011; 95: 366-368

  • 45.
    • Lobo RA
    • Rosen RC
    • Yang HM
    • Block B
    • Van Der Hoop RG

    Comparative results of oral esterified estrogens with and with out methyltestosterone on endocrine profiles and dimensions of sexual perform in postmenopausal girls with hypoactive sexual want.

    Fertil Steril. 2003; 79: 1341-1352

  • 46.
    • Miller BE
    • De Souza MJ
    • Slade Okay
    • Luciano AA

    Sublingual administration of micronized estradiol and progesterone, with and with out micronized testosterone: impact on biochemical markers of bone metabolism and bone mineral density.

    Menopause. 2000; 7: 318-326

  • 47.
    • Moller MC
    • Bartfai AB
    • Radestad AF

    Effects of testosterone and estrogen substitute on reminiscence perform.

    Menopause. 2010; 17: 983-989

  • 48.
    • Moller MC
    • Radestad AF
    • von Schoultz B
    • Bartfai A

    Effect of estrogen and testosterone substitute remedy on cognitive fatigue.

    Gynecol Endocrinol. 2013; 29: 173-176

  • 49.
    • Nathorst-Boos J
    • Floter A
    • Jarkander-Rolff M
    • Carlstrom Okay
    • Von Schoultz B

    Treatment with percutanous testosterone gel in postmenopausal girls with decreased libido: results on sexuality and psychological normal well-being.

    Maturitas. 2006; 53: 11-18

  • 50.
    • Panay N
    • Al-Azzawi F
    • Bouchard C
    • et al.

    Testosterone therapy of HSDD in naturally menopausal girls: the ADORE examine.

    Climacteric. 2010; 13: 121-131

  • 51.
    • Penteado SRL
    • Fonseca AM
    • Bagnoli VR
    • Abdo CHN
    • Soares Jr, JM
    • Baracat EC

    Effects of the addition of methyltestosterone to mixed hormone remedy with estrogens and progestogens on sexual power and on orgasm in postmenopausal girls.

    Climacteric. 2008; 11: 17-25

  • 52.
    • Shifren JL
    • Braunstein GD
    • Simon JA
    • et al.

    Transdermal testosterone therapy in girls with impaired sexual perform after oophorectomy.

    N Engl J Med. 2000; 343: 682-688

  • 53.
    • Shifren JL
    • Davis SR
    • Moreau M
    • et al.

    Testosterone patch for the therapy of hypoactive sexual want dysfunction in naturally menopausal girls: outcomes from the INTIMATE NM1 Study.

    Menopause. 2006; 13: 770-779

  • 54.
    • Simon J
    • Braunstein G
    • Nachtigall L
    • et al.

    Testosterone patch will increase sexual exercise and want in surgically menopausal girls with hypoactive sexual want dysfunction.

    J Clin Endocrinol Metab. 2005; 90: 5226-5233

  • 55.
    • Simon J
    • Klaiber E
    • Wiita B
    • Bowen A
    • Yang HM

    Differential results of estrogen-androgen and estrogen-only remedy on vasomotor signs, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal girls.

    Menopause. 1999; 6: 138-146

  • 56.
    • Watts NB
    • Notelovitz M
    • Timmons MC
    • Addison WA
    • Wiita B
    • Downey LJ

    Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal signs, and lipid-lipoprotein profiles in surgical menopause.

    Obstet Gynecol. 1995; 85: 529-537

  • 57.
    • Wisniewski AB
    • Nguyen TT
    • Dobs AS

    Evaluation of high-dose estrogen and high-dose estrogen plus methyltestosterone therapy on cognitive job efficiency in postmenopausal girls.

    Horm Res. 2002; 58: 150-155

  • 58.
  • 58.

    Endometrial security examine of transdermal testosterone (300 mcg/day) in naturally postmenopausal girls.

  • 59.
    • Rosen R
    • Brown C
    • Heiman J
    • et al.

    The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the evaluation of feminine sexual perform.

    J Sex Marital Ther. 2000; 26: 191-208

  • 60.
    • McHorney CA
    • Rust J
    • Golombok S
    • et al.

    Profile of Female Sexual Function: a patient-based, worldwide, psychometric instrument for the evaluation of hypoactive sexual want in oophorectomized girls.

    Menopause. 2004; 11: 474-483

  • 61.
    • Davison SL
    • Bell RJ
    • LaChina M
    • Holden SL
    • Davis SR

    Sexual perform in properly girls: stratification by sexual satisfaction, hormone use, and menopause standing.

    J Sex Med. 2008; 5: 1214-1222

  • 62.
    • Richters J
    • Grulich AE
    • de Visser RO
    • Smith AM
    • Rissel CE

    Sex in Australia: sexual and emotional satisfaction in common relationships and most well-liked frequency of intercourse amongst a consultant pattern of adults.

    Aust NZ J Public Health. 2003; 27: 171-179

  • 63.
    • Witting Okay
    • Santtila P
    • Varjonen M
    • et al.

    Couples’ sexual dysfunctions: feminine sexual dysfunction, sexual misery, and compatibility with associate.

    J Sex Med. 2008; 5: 2587-2599

  • 64.
    • Simon JA
    • Davis SR
    • Althof SE
    • et al.

    Sexual well-being after menopause: an International Menopause Society White Paper.

    Climacteric. 2018; 21: 415-427

  • 65.
    • Worboys S
    • Kotsopoulos D
    • Teede H
    • McGrath B
    • Davis S

    Parental testosterone improves endothelium-dependent and unbiased vasodilation in postmenopausal girls already receiving estrogen.

    J Clin Endocrinol Metab. 2001; 86: 158-161

  • 66.

    Testosterone remedy in girls: myths and misconceptions.

    Maturitas. 2013; 74: 230-234

  • 67.
    • Gera R
    • Tayeh S
    • Chehade HE-H
    • Mokbel Okay

    Does transdermal testosterone enhance the danger of growing breast most cancers? A systematic review.

    Anticancer Res. 2018; 38: 6615-6620

  • 68.
    • Snabes M
    • Zborowski J
    • Simes S

    Libigel doesn’t differentiate from placebo remedy within the therapy of hypoactive sexual want in postmenopausal girls.

    J Sex Med. 2012; 9: 171

  • 69.

    ‘BLOOM’ off the rose: LibiGel failure sends BioSante falling.

  • Source link

    Load More Related Articles
    Load More By Health Master
    Load More In Health News

    Leave a Reply

    Your email address will not be published. Required fields are marked *

    Check Also

    SUMMER SKINCARE ROUTINE FOR OILY SKIN , NORMAL SKIN & DRY SKIN |TipsToTop By Shalini

    Product Used- 1. Himalaya Neem Facewash- 2. Himalaya Apricot Scrub- 3. Wow Aloe Vera gel- …