Researchers at Tel Aviv University revealed within the August 5 problem of Nature Nanotechnology a novel nano-vaccine for melanoma, essentially the most aggressive sort of pores and skin most cancers.
Their revolutionary method has up to now confirmed efficient in stopping the event of melanoma in mouse fashions and in treating main tumors and metastases that outcome from melanoma.
Melanoma develops within the pores and skin cells that produce melanin or pores and skin pigment.
“The war against cancer in general, and melanoma in particular, has advanced over the years through a variety of treatment modalities, such as surgery, chemotherapy, radiation therapy and immunotherapy; but the vaccine approach, which has proven so effective against various viral diseases, has not materialized yet against cancer,” mentioned examine chief Prof. Ronit Satchi-Fainaro, chair of the division of physiology and pharmacology and head of the Laboratory for Cancer Research and Nanomedicine at TAU’s Sackler Faculty of Medicine.
“In our study, we have shown that it is possible to produce an effective nano-vaccine against melanoma and to sensitize the immune system to immunotherapies.”
Satchi-Fainaro and University of Lisbon Prof. Helena Florindo, who was on sabbatical on the Satchi-Fainaro lab, led the analysis performed by Anna Scomparin of Satchi-Fainaro’s lab and postdoctoral fellow Dr. João Conniot.
The researchers harnessed tiny particles, about 170 nanometers in dimension, product of a biodegradable polymer. Within every particle, they “packed” two peptides — quick chains of amino acids, that are expressed in melanoma cells. They then injected the nanoparticles (or “nano-vaccines”) right into a mouse mannequin bearing melanoma.
“The nanoparticles acted just like known vaccines for viral-borne diseases,” Satchi-Fainaro reported. “They stimulated the immune system of the mice, and the immune cells learned to identify and attack cells containing the two peptides — that is, the melanoma cells. This meant that, from now on, the immune system of the immunized mice will attack melanoma cells if and when they appear in the body.”
The researchers demonstrated the effectiveness of the vaccine underneath three totally different situations: as a safety measure in healthy mice; to deal with a main tumor in mice along side immunotherapy; and to deal with tissues taken from sufferers with melanoma mind metastases.
“Our research opens the door to a completely new approach — the vaccine approach — for effective treatment of melanoma, even in the most advanced stages of the disease,” mentioned Satchi-Fainaro. “We believe that our platform may also be suitable for other types of cancer and that our work is a solid foundation for the development of other cancer nano-vaccines.”