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Updating Our Microbiome Software and Hardware

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Good micro organism, these residing in symbiosis with us, are nourished by fruits, greens, grains, and beans, whereas unhealthy micro organism, these in dysbiosis with us and probably contributing to illness, are fed by meat, junk food and quick food, seafood, dairy, and eggs, as you may see at 0:12 in my video Microbiome: We Are What They Eat. Typical Western diets can “decimate” our good intestine flora.

We reside with trillions of symbionts, good micro organism that reside in symbiosis with us. We assist them, and they assist us. A month on a plant-based weight loss plan ends in a rise within the inhabitants of the great guys and a lower within the unhealthy, the so-called pathobionts, the disease-causing bugs. “Given the disappearance of pathobionts from the intestine, one would expect to observe a reduction in intestinal inflammation in subjects.” So, researchers measured stool concentrations of lipocalin-2, “which is a sensitive biomarker of intestinal inflammation.” As you may see at 1:13 in my video, inside a month of eating healthfully, it had “declined significantly…suggesting that promotion of microbial homeostasis”—or stability—“by an SVD [strict vegetarian diet] resulted in reduced intestinal inflammation.” What’s extra, this rebalancing might have performed a job “in improved metabolic and immunological parameters,” that’s, in immune system parameters.

In distinction, on an “animal-based diet,” you get progress of disease-associated species like Bilophila wadsworthia, related to inflammatory bowel illness, and Alistipes putredinis, present in abscesses and appendicitis, and a lower in fiber-eating micro organism. When we eat fiber, the fiber-munching micro organism multiply, and we get extra anti-inflammatory, anti-cancer short-chain fatty acids. When we eat much less fiber, our fiber-eating micro organism starve away.

They are what we eat.

Eat lots of phytates, and our intestine flora get actually good at breaking down phytates. We assumed this was simply because we have been naturally deciding on for these populations of micro organism in a position to try this, nevertheless it seems our weight loss plan can educate previous bugs new methods. There’s one kind of fiber in nori seaweed that our intestine micro organism can’t usually breakdown, however the micro organism within the ocean that eat seaweed have the enzyme to take action. When it was found that that enzyme was present within the guts of Japanese folks, it offered a thriller. Sure, sushi is eaten uncooked, so some seaweed micro organism might have made it to their colons, however how might some marine micro organism thrive within the human intestine? It didn’t have to. It transferred the nori-eating enzyme to our personal intestine micro organism.

“Consequently, the consumption of food with associated environmental bacteria is the most likely mechanism that promoted this CAZyme [enzyme] update into the human gut microbe”—nearly like a software program replace. We have the identical {hardware}, the identical intestine micro organism, however the micro organism simply up to date their software program to allow them to chew on one thing new.

Hardware can change, too. A research titled “The way to a man’s heart is through his gut microbiota” was so named as a result of the researchers have been speaking about TMAO, trimethylamine N-oxide. As you may see at 3:33 in my video, sure intestine flora can take carnitine from the pink meat we eat or the choline concentrated in dairy, seafood, and eggs, and convert it right into a poisonous compound, which can result in a rise in our threat of coronary heart assault, stroke, and demise.

This explains why these eating extra plant-based diets have decrease blood concentrations of TMAO. However, in addition they produce much less of the toxin even in case you feed them a steak. You don’t see the identical “conversion of dietary L-carnitine to TMAO…suggesting an adoptive response of the gut microbiota in omnivores.” They are what we feed them.

As you may see at 4:17 in my video, in case you give folks cyclamate, an artificial synthetic sweetener, most of their micro organism don’t know what to do with it. But, in case you feed it to folks for ten days and choose for the few micro organism that have been hip to the brand new artificial chemical, finally three quarters of the cyclamate consumed is metabolized by the micro organism into one other new compound referred to as cyclohexylamine. Stop eating it, nonetheless, and these micro organism die again. Unfortunately, cyclohexylamine could also be poisonous and so was banned by the FDA in 1969. In a classic Kool-Aid advert from 1969, Pre-Sweetened Kool-Aid was taken “off your grocer’s shelves,” however Regular Kool-Aid “has no cyclamates” and “is completely safe for your entire family.”

But, in case you simply ate cyclamate on occasion, it wouldn’t flip into cyclohexylamine since you wouldn’t have fed and fostered the intestine flora specialised to take action. The similar factor occurs with TMAO. Those who simply eat pink meat, eggs, or seafood on occasion would presumably make little or no of the toxin as a result of they hadn’t been cultivating the micro organism that produce it.


Here’s the link to my video on TMAO: Carnitine, Choline, Cancer, and Cholesterol: The TMAO Connection. For an replace on TMAO, see How Our Gut Bacteria Can Use Eggs to Accelerate Cancer, Egg Industry Response to Choline and TMAO, and How to Reduce Your TMAO Levels.

Interested in additional on holding our intestine bugs glad? See:

In health,

Michael Greger, M.D.

PS: If you haven’t but, you may subscribe to my free movies right here and watch my reside displays:

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